A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A61K 39/104 (2006.01) A61K 47/48 (2006.01) C07K 7/23 (2006.01) C07K 14/21 (2006.01) C07K 16/26 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2233882
Pseudomonas exotoxin and variants thereof are potent immunogenic carrier proteins for GnRH. Vaccines containing a GnRH associated with Pseudomonas exotoxin are capable of eliciting high titres of anti-GnRH antibodies in animals, and are therefore useful for controlling fertility, reducing undesirable reproductive hormone driven behaviors, and treating sex steroid responsive tumors.
L'exotoxine de Pseudomonas et certaines de ses variantes sont des protéines vecteurs immunogènes puissantes de la GnRH. Les vaccins contenant une GnRH en association avec l'exotoxine de Pseudomonas permettent d'obtenir chez des animaux des titres élevés d'anticorps anti-GnRH. Il en résulte que de tels vaccins conviennent particulièrement au contrôle de la fertilité, à l'atténuation des comportements indésirables dépendants des hormones de reproduction, et au traitement des tumeurs réagissant aux stéroïdes sexuels.
Hickey Gerard J.
Mohn Kenneth L.
Merck & Co. Inc.
Swabey Ogilvy Renault
LandOfFree
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