Pseudomonas peptide composition and method for producing the...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/21 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 39/104 (2006.01) A61K 39/40 (2006.01) A61K 47/48 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 16/12 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2098296

A peptide having a sequence corresponding to a C-terminal portion of the Pseudomonas aeruginosa pilin protein is disclosed. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against such cross-reactive microorganisms. Also disclosed are methods of preparing peptides which are cross-reactive with the P. aeruginosa pilin peptide, and chimeric monoclonal antibodies immunoreactive with the pilin peptide.

Peptide présentant une séquence correspondant à une portion C-terminale de la protéine piline de Pseudomonas aeruginosa. Ce peptide, qui entre en réaction croisée avec les peptides de surface présents dans certains microorganismes bactériens et fongiques, réussit à inhiber la liaison de ces organismes aux cellules épithéliales cibles. Il pourrait aussi entrer dans la composition d'un vaccin procurant une immunité contre ce genre de microorganismes à réaction croisée. Sont également décrits les modes de préparation de peptides entrant en réaction croisée avec le peptide piline de P. aeruginosa, et d'anticorps monoclonaux chimères entrant en immunoréaction avec le peptide piline.

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