Pseudomycin phosphate prodrugs

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61P 31/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2396513

A pseudomycin prodrug represented by structure (A) where R1 is a phosphate benzyloxycarbamate or phosphate methyleneoxycarbamate linkage is described. The phosphate prodrug demonstrates antifungal activity with less adverse side effects than the parent pseudomycin compound.

La présente invention concerne un promédicament de pseudomycine, représenté par la structure (A), dans laquelle R1 est une liaison benzyloxycarbamate de phosphate ou méthylèneoxycarbamate de phosphate. Ces promédicaments de phosphate présentent une activité antifongique, avec moins d'effets indésirables que le composé de pseudomycine parent.

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