Pseudopeptide compounds having an inhibiting activity with...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 5/033 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/18 (2006.01) A61P 35/00 (2006.01) C07K 5/02 (2006.01) C07K 5/08 (2006.01) C07K 5/087 (2006.01) C07K 14/71 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2356777

The invention concerns a compound corresponding to general formula (I) wherein, in particular: R¿2? represents a phenylmethyl or naphthylmethyl or cyclohexylmethyl radical, 2- and 3-pyridinylmethyl, substituted on the cycle in meta or para position by an acid group or an alkyl radical of the type (CH¿2?)¿n? (with n = 3 or 4) substituted in terminal position by an acid group; and R¿3? represents a hydrogen group or a linear or branched C¿1?-C¿4? alkyl or alkylcycloalkyl with a C¿3?-C¿6? cycloalkyl. The invention also concerns the use of a compound of general formula (I) for preparing a pharmaceutical composition for treating diseases related to proliferative processes, cancers and/or metastases.

L'invention a pour objet un composé répondant à la formule générale (I) dans laquelle notamment: R2 représente un radical phénylméthyle ou naphtylméthyle ou cyclohexylméthyle, 2- et 3-pyridinylméthyle, substitué sur le cycle en position para ou méta par un groupement acide ou un radical alkyle de type (CH2)n (avec n = 3 ou 4) substitué en position terminale par un groupement acide; et R3 représente un groupement hydrogène ou alkyle en C1 à C4, linéaire ou ramifié ou alkylcycloalkyle avec un cycloalkyle en C3 à C6. Elle a également pour objet l'utilisation d'un composé de formule générale (I) pour la préparation d'une composition pharmaceutique destinée au traitement des maladies liées à des processus prolifératifs, des cancers et/ou métastases.

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