C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/08 (2006.01) A61K 31/495 (2006.01) C07D 295/088 (2006.01)
Patent
CA 2310318
The present invention relates to new pseudopolymorphic forms of 2-[2-[4-[bis(4- fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride, namely, anhydrous 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride and 2-[2-[4-[bis(4-fluorophenyl)methyl]-1- piperazinyl]ethoxy]acetic acid dihydrochloride monohydrate. It also relates to processes for the preparation of these pseudopolymorphic forms and to pharmaceutical compositions containing them.
L'invention concerne des nouvelles formes pseudomorphes de dichlorhydrate d'acide 2-[2-[4-[bis(4-fluorophényl)méthyl]-1-pipérazinyl]éthoxy]acétique, à savoir de dichlorhydrate d'acide 2-[2-[4-[bis(4-fluorophényl)méthyl]-1-pipérazinyl]éthoxy]acétique et de monohydrate de dichlorhydrate d'acide 2-[2-[4-[bis(4-fluorophényl)méthyl]-1-pipérazinyl]éthoxy]acétique. Elle porte aussi sur des procédés de préparation desdites formes pseudomorphes et sur des compositions pharmaceutiques les contenant.
Berwaer Monique
Bodson Guy
Deleers Michel
Dogimont Charles
Fanara Domenico
Robic
Ucb S.a.
Ucb Pharma S.a.
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