Pseudopterosin and synthetic derivatives thereof

Details Pseudopterosin and synthetic derivatives thereof Pseudopterosin and synthetic derivatives thereof

C - Chemistry, Metallurgy

07

H

167/199, 260/233

C07H 15/256 (2006.01) A61K 31/70 (2006.01)

Patent

CA 1317591

DOCKET NO. 65-209 PSEUDOPTEROSIN AND SYNTHETIC DERIVATIVES THEREOF Abstract of the Disclosure Methods for treating mammals to reduce pain, reduce cell proliferation and/or reduce inflammation are de- scribed based on administering to the mammals compounds having the formula Image wherein R1, R2, R3 and R4 are hydrogen or an acyl group having from 1 to 6 carbon atoms; R5 is hydrogen, CH3 or CH2OH and R6 is a hydrocarbon having from 1 to 10 carbon atoms. Natural and synthetic 1,12-seco derivatives with similar utilities are disclosed. Natural and synthetic derivatives are also disclosed where the sugar moiety is attached at the C-10 carbon on the tricyclic diterpene moiety instead of the C-9 carbon.

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