Pseudorabies virus mutants, vaccines containing same,...

Details Pseudorabies virus mutants, vaccines containing same,... Pseudorabies virus mutants, vaccines containing same,...

C - Chemistry, Metallurgy

12

N

167/130, 195/1.2

C12N 15/00 (2006.01) A61K 39/245 (2006.01) C07K 14/03 (2006.01) C12N 7/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1264688

PSEUDORABIES VIRUS MUTANTS, VACCINES CONTAINING SAME, METHODS FOR THE PRODUCTION OF SAME AND METHODS FOR THE USE OF SAME ABSTRACT The present invention relates to pseudorabies virus mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced. As a result, animals vaccinated with such do not develop antibodies to the viral glycoprotein and can be distinguished from animals infected with pseudorabies virus field strains and known pseudorabies virus vaccine strains. The present invention also relates to vaccines for pseudorabies disease containing the same, methods for production of the same and methods for use of the same.

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