C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 14/145 (2006.01) C12N 5/10 (2006.01) C12N 7/04 (2006.01) C12N 15/867 (2006.01)
Patent
CA 2448947
The invention relates to a defective lentivirus which is pseudotyped with a lyssavirus envelope of the PV (rabies virus) or MOK type (Mokola virus), for example, and to the use thereof, especially in the preparation of a composition for in vivo transfer of genes in astrocytes and also for the treatment of disorders of the central nervous system.
L'invention décrit un lentivirus défectif pseudotypé avec une enveloppe de lyssavirus, par exemple de type PV (virus de la Rage) ou MOK (virus Mokola) ainsi que ses utilisations notamment pour la préparation d'une composition destinée au transfert de gènes dans des astrocytes in vivo et également pour le traitement de désordres du système nerveux central.
Dufour Noelle
He Yi
Mallet Jacques
Sarkis Chamsy
Serguera Che
Biovectys
Centre National de La Recherche Scientifique
Robic
LandOfFree
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