Psma antibodies and protein multimers

Details Psma antibodies and protein multimers Psma antibodies and protein multimers

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 5/12 (2006.01) G01N 33/53 (2006.01) G01N 33/554 (2006.01)

Patent

CA 2464239

The invention includes antibodies or antigen-binding fragments thereof which bind specifically to conformational epitopes on the extracellular domain of PSMA, compositions containing one or a combination of such antibodies or antibodies or antigen-binding fragments thereof, hybridoma cell lines that produce the antibodies, and methods of using the antibodies or antigen-binding fragments thereof for cancer diagnosis and treatment. The invention also includes oligomeric forms of PSMA proteins, compositions comprising the multimers, and antibodies that selectively bind to the multimers.

L'invention a trait à des anticorps et à des Fab desdits anticorps, qui se lient spécifiquement à des déterminants antigéniques conformationnels sur le domaine extracellulaire de PSMA, à des compositions contenant un tel anticorps ou un tel Fab ou une combinaison de ces derniers, à des lignées cellulaires hybridomes qui produisent lesdits anticorps, et à des méthodes consistant à utiliser les anticorps ou les Fab pour le diagnostic et le traitement du cancer. L'invention concerne également des formes oligomériques de protéines PSMA, des compositions contenant les multimères, et des anticorps qui se lient spécifiquement aux multimères.

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