Psma-binding agents and uses thereof

Details Psma-binding agents and uses thereof Psma-binding agents and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 213/61 (2006.01) A61K 31/195 (2006.01) A61K 31/44 (2006.01) A61K 51/04 (2006.01) A61P 35/00 (2006.01) C07C 275/16 (2006.01) C07D 213/82 (2006.01) G01N 33/60 (2006.01)

Patent

CA 2732632

Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.

Cette invention concerne des composés de liaison à lantigène prostatique spécifique membranaire (PSMA) ayant des substituants radio-isotopes, ainsi que leurs précurseurs chimiques. Linvention concerne aussi des composés comprenant des composés à pyridine, des composés à structures phénylhydrazine et des composés à lysine acylée. Les composés permettent une incorporation facile de radionucléides pour la tomographie d'émission à photon unique (TEPU) et la tomographie d'émission par positons (TEP) pour limagerie, par exemple, les cellules du cancer de la prostate et langiogenèse.

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