Psma formulations and uses thereof

Details Psma formulations and uses thereof Psma formulations and uses thereof

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C07K 1/16 (2006.01) C07K 14/705 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2543703

The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, including methods of producing antibodies to dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.

L'invention concerne des formes stables multimères, en particulier dimères de la protéine PSMA, des compositions et des nécessaires contenant une forme dimère de la protéine PSMA, ainsi que des procédés pour produire, purifier et utiliser lesdites compositions. Parmi ces procédés figurent des procédés pour induire ou renforcer une réponse immunitaire envers des cellules qui expriment la protéine PSMA, y compris des procédés pour produire des anticorps contre une forme dimère de la protéine PSMA, et des procédés pour traiter le cancer, par exemple le cancer de la prostate.

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