Psmcs as modifiers of the rb pathway and methods of use

Details Psmcs as modifiers of the rb pathway and methods of use Psmcs as modifiers of the rb pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2494252

Human PSMC genes are identified as modulators of the RB pathway, and thus are therapeutic targets for disorders associated with defective RB function. Methods for identifying modulators of RB, comprising screening for agents that modulate the activity of PSMC are provided.

On a identifié des gènes PSMC humains comme étant des modulateurs du trajet RB et, ceux-ci sont des cibles thérapeutiques pour des troubles associés à une fonction RB défectueuse. Cette invention concerne aussi des techniques d'identification de modulateurs de RB, qui consistent à rechercher des agents modulant l'activité de PSMC.

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