Psoralen conjugated methylphosphonate oligonucleotides as...

Details Psoralen conjugated methylphosphonate oligonucleotides as... Psoralen conjugated methylphosphonate oligonucleotides as...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07D 493/04 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2089088

2089088 9202641 PCTABS00010 Novel reagents which are useful for conjugating a psoralen moiety to an oligomer having at least one non-nucleotide monomeric unit are provided. Also provided are psoralen-conjugated oligomers. Psoralen-conjugated oligomers complementary to the abl gene or bcr/abl of chimeric mRNA are useful in decreasing expression of abl-associated tyrosine kinase and P210 protein.

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