Psoriasin expression by breast epithelial cells

Details Psoriasin expression by breast epithelial cells Psoriasin expression by breast epithelial cells

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2472163

The invention features methods of diagnosing high grade ductal carcinoma in situ (DCIS). These methods involve measuring: (1) the level of HID-5 in a body fluid (e.g., blood or urine) of a subject suspected of having, or at risk of having, high grade DCIS; or (2) the level of HID-5 gene expression in breast tissue from a subject suspected of having, or at risk of having, high grade DCIS. The invention also embodies a method of inhibiting expression of HID-5 protein in DCIS cells and methods of treating a subject suspected of having, or at risk of having, high grade DCIS.

Cette invention concerne des méthodes permettant de diagnostiquer un carcinome canalaire in situ (CCIS) de haut grade de malignité. Ces méthodes consistent à mesurer : (1) la teneur en HID-5 dans un fluide corporel (tel que le sang ou l'urine) chez un sujet souffrant ou susceptible de souffrir d'un carcinome canalaire in situ (CCIS) de haut grade de malignité ; ou (2) le niveau d'expression du gène HID-5 dans des tissus mammaires chez un sujet souffrant ou susceptible de souffrir d'un CCIS de haut grade de malignité. Cette invention concerne également une méthode permettant d'inhiber l'expression de la protéine HID-5 dans des cellules CCIS ainsi que des méthodes permettant de traiter un sujet souffrant ou susceptible de souffrir de CCIS de haut grade de malignité.

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