Psp94 diagnostic reagents and assays

Details Psp94 diagnostic reagents and assays Psp94 diagnostic reagents and assays

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 17/00 (2006.01) C07K 19/00 (2006.01) C12N 5/16 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2426589

In the serum, PSP94 occurs as a free form or is associated with a carrier protein. PSP94 in its bound form has been quantified in the blood of prostate cancer patients and these measurements have shown utility as evaluation of prognosis. The present invention identifies a carrier protein to which PSP94 is bound (named PSP94-binding protein) its purification process, its nucleic acid and amine acid sequence and to the use of these sequences in the diagnosis and prognosis of PSP94 related disease. More particularly, the present invention discloses improved diagnostic and prognostic assays as well as reagents useful for the evaluation of conditions linked with abnormal or elevated levels of PSP94, such as prostate cancer and benign prostatic hyperplasia.

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