C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/7.08
C07K 14/675 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2021880
Abstract of the disclosure Disclosed are novel (6-17) .beta.-endorphin fragments which possess a derivatized lysine at site 9. The peptides have the amino acid sequence according to the general formula: (I) Image wherein X is a derivatized lysine, selected from the group Lys-Ac, Lys(Z), des-Lys, A2hy, Nle, Met, Leu or Lys [(ar)alkyl]; R1 is Ser, Ala or Pro; R2 is L-Gln, D-Gln, Glu(tyramine) or iodine-containing derivatives thereof; and R3 is L-Leu, Leu-NHCH3, Met, Phe, Phe(Cl), Phe(I), Cha, Mag, Val, (HO)Leu, Bua or Bug. Methods of making the fragments are also described.
Akzo N.v.
Fetherstonhaugh & Co.
Van Nispen Johannes W. F. M.
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