Psychotropic bicyclic imides

Details Psychotropic bicyclic imides Psychotropic bicyclic imides

C - Chemistry, Metallurgy

07

D

260/263, 260/266

C07D 221/22 (2006.01) C07D 221/24 (2006.01) C07D 498/08 (2006.01) C07D 513/08 (2006.01)

Patent

CA 1335502

Substituted imides of the following formula are antipsychotic, anxiolytic agents with very little extrapyramidal side effects: Image in which X is -O-, -S-, -SO-, -SO2-, -CR3R4- where R3 and R4, independently, are hydrogen, alkyl of 1 to 4 carbon atoms or, taken together with the carbon atom to which they are attached, R3 and R4 form a cycloalkyl group of 3 to 5 carbon atoms; Y is alkylene of 1 to 3 carbon atoms or alkenylene of 2 to 3 carbon atoms; n is one of the integers 0 or 1; m is one of the integers 2, 3, 4 or 5; R is 2-pyrimidinyl, halopyrimidin-2-yl, 2-pyrazinyl, halopyrazin-2-yl, 2- pyridinyl, cyanopyridin-2-yl, halopyridin-2-yl, quinolyl, or haloquinolyl; or a pharmaceutically acceptable salt thereof.

562257

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