Pt32 sperm protein, oocyte cytoplasmic c-yes, and uses thereof

Details Pt32 sperm protein, oocyte cytoplasmic c-yes, and uses thereof Pt32 sperm protein, oocyte cytoplasmic c-yes, and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12P 21/00 (2006.01) C12Q 1/22 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2307128

The perinuclear theca 32 (PT32) protein is disclosed and shown to interact with tyrosine kinase c-Yes. PT32, c-Yes, fragments thereof, and molecules that bind thereto can be used in methods of enhancing fertility, treating or diagnosing diminished fertility and abnormal spermiogenesis, in providing contraception, and in identifying contraceptive and fertility-enhancing agents. Transgenic, non- human animals also are disclosed.

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