Pt32 sperm protein, sperm c-yes, oocyte cytoplasmic c-yes,...

Details Pt32 sperm protein, sperm c-yes, oocyte cytoplasmic c-yes,... Pt32 sperm protein, sperm c-yes, oocyte cytoplasmic c-yes,...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/00 (2006.01) A61K 38/17 (2006.01) A61K 38/45 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/00 (2006.01) C12N 5/00 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2408022

The perinuclear theca 32(PT32) protein is disclosed and shown to interact with tyrosine kinase c-Yes. PT32, c-Yes, fragments thereof, and molecules that bind thereto can be used in methods of enhancing fertility, treating or diagnosing diminished fertility and abnormal spermiogenesis, in providing contraception, and in identifying contraceptive and fertility-enhancing agents. Transgenic, non-human animals also are disclosed.

L'invention concerne la protéine thécale périnucléaire 32 (PT32), qui interagit avec la tyrosine kinase c-Yes. PT32, c-Yes, leurs fragments et des molécules qui se lient à elles peuvent être utilisés dans des méthodes qu'on met en oeuvre pour augmenter la fécondité, traiter ou diagnostiquer une baisse de la fécondité ou la spermiogenèse, et dans des méthodes de contraception ou d'identification d'agents contraceptifs ou d'augmentation de la fécondité. L'invention concerne en outre des animaux non humains transgéniques.

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