C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/242
C07D 475/08 (2006.01) A61K 31/505 (2006.01)
Patent
CA 1252783
ABSTRACT Pteridine Derivatives New pteridines of formula (I) Image (wherein R2 represents a piperazino or N-formyl-piperazino group, R4 represents a dialkylamino, phenylalkylamino, N-alkyl-phenylalkylamino, pyrrolidino, piperidino, morpholino, thiomorpholino, 1-oxidothiomorpholino, thiazolidino or 1-oxidothiazolidino group, R6 represents a hydrogen atom or an alkyl or phenyl group, and R7 represents an alkylamino, dialkylamino, phenylalkylamino, N-alkyl-phenylalkylamino, piperidino, morpholino, thiomorpholino, 1-oxidothiomorpholino or piperazino group; wherein each alkyl moiety in groups R4, R6 and R7 contains from 1 to 3 carbon atoms; wherein, where R4 contains one or two C2-3 alkyl moieties, one or both of said C2-3 alkyl moieties may be substituted by a hydroxy group in the 2 or 3 position; and wherein, where R7 contains one or two C2-3 alkyl moieties, one or both of said C2-3 alkyl moieties may be substituted by a hydroxy group in the 2 or 3 position) and the acid addition salts thereof are disclosed. When R2 represents an N-formyl-piperazino group, these are valuable intermediate products for preparing the pteridines of formula I in which R2 represents a piperazino group, which have valuable pharmacological properties, more particularly antithrombotic and metastasis-inhibiting effects and an inhibiting activity on tumour growth.
497336
Heckel Armin
Muller Erich
Narr Berthold
Nickl Josef
Roch Josef
Fetherstonhaugh & Co.
Thomae (dr. Karl) Gesellschaft Mit Beschrankter Haftung
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