Pteridinone derivatives for use as stearoyl coa desaturase...

Details Pteridinone derivatives for use as stearoyl coa desaturase... Pteridinone derivatives for use as stearoyl coa desaturase...

C - Chemistry, Metallurgy

07

D

C07D 475/00 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2681560

The present invention discloses pteridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula (I) The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.

La présente invention concerne des dérivés de ptéridinone destinés à être utilisés comme des inhibiteurs de stéaroyl-CoA désaturase ayant la structure de formule (I). Les composés sont utiles dans le traitement et/ou la prévention de diverses maladies humaines, médiées par des enzymes stéaroyl-CoA désaturases (SCD), en particulier les maladies liées à des taux de lipides anormaux, les maladies cardiovasculaires, les diabètes, l'obésité, le syndrome métabolique et les maladies similaires.

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