Pthrp-derived modulators of smooth muscle proliferation

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/00 (2006.01) C07K 14/575 (2006.01) C07K 16/26 (2006.01) C07K 16/46 (2006.01) C12N 5/00 (2006.01) C12N 15/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2535748

The present invention relates to the use of mutants of parathyroid hormone- related protein, to treat disorders associated with smooth muscle cells, and to inhibit the cellular activation and proliferation thereof. The method can be employed in diverse tissues to effect therapeutic and prophylactic relief for disorders and diseases manifested by activation of smooth muscle that can lead to excessive smooth muscle proliferation. For example, where employed in the vasculature, the inventive method can be used to treat restenosis following angioplasty.

L'invention concerne l'utilisation de mutants de la protéine liée à l'hormone parathyroïde pour traiter des troubles associés aux cellules du muscle lisse, et inhiber l'activation cellulaire et la prolifération de celles-ci. Le procédé peut être appliqué dans divers tissus pour traiter et prévenir des troubles et des maladies se manifestant par l'activation du muscle lisse et pouvant entraîner une prolifération excessive de muscle lisse. Par exemple, lorsqu'on l'applique à des vaisseaux, le procédé permet de traiter la resténose consécutive à une angioplastie.

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