C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/26 (2006.01) A61K 39/395 (2006.01) A61K 49/16 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 14/635 (2006.01) C12N 5/16 (2006.01) C12N 15/12 (2006.01) C12N 15/16 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2696684
The present invention is directed to the diagnosis and treatment of diseases, preferably the inhibition of tumor growth and its progression to metastatic sites, through the inhibition of the action or production of PTHrP, its isoforms or PTHrP signalling. An aspect of the present invention is also directed to methods of inhibiting the PTHrP1-173 isoform through antagonists thereof, including monoclonal antibodies and siRNA directed there against. The invention may be applicable to many disease states, including but not limited to several types of cancer (including epithelial cancers such as breast, lung, colon, pancreatic, ovarian, prostate and squamous as well as melanoma) expressing PTHrP and its isoforms, alone or in combination with other therapeutic agents.
La présente invention porte sur le diagnostic et le traitement de maladies, de préférence sur l'inhibition de la croissance tumorale et de sa progression vers des sites métastasiques, par inhibition de l'action ou de la production de PTHrP, de ses isoformes ou d'une signalisation par PTHrP. Un aspect de la présente invention porte également sur des procédés consistant à inhiber l'isoforme PTHrP1-173 par des antagonistes de celle-ci, comprenant des anticorps monoclonaux et de l'ARNsi dirigés contre celle-ci. L'invention peut être applicable à de nombreuses pathologies comprenant, mais sans y être limités, divers types de cancer (dont les cancers épithéliaux tels que le cancer du sein, du poumon, du côlon, des ovaires, de la prostate et les cancers pancréatiques et squameux ainsi que le mélanome) exprimant PTHrP et ses isoformes, seuls ou en combinaison avec d'autres agents thérapeutiques.
Huang Dao Chao
Kremer Richard
Biochrom Pharma Inc.
Fasken Martineau Dumoulin Llp
LandOfFree
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