Ptp-d subfamily of protein tyrosine phosphatases

Details Ptp-d subfamily of protein tyrosine phosphatases Ptp-d subfamily of protein tyrosine phosphatases

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 38/46 (2006.01) C07K 16/40 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/16 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/42 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2141847

2141847 9403611 PCTABS00030 A novel subfamily (PTP-D) of protein tyrosine phosphatases is identified. Included in this family are PTP-D proteins or glycoproteins having one, two, or three identified amino acid changes in previously defined consensus sequences in the catalytic phosphatase domains of known protein tyrosine phosphatases. The PTP-D proteins or glycoproteins may be produced by recombinant means. Antibodies to PTP-D proteins or glycoproteins and nucleic acid constructs coding therefor, and methods for screening molecules which can bind to PTP-D proteins or glycoproteins and inhibit or stimulate their enzymatic activity, are provided.

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