Pufa polyketide synthase systems and uses thereof

Details Pufa polyketide synthase systems and uses thereof Pufa polyketide synthase systems and uses thereof

C - Chemistry, Metallurgy

12

P

C12P 7/64 (2006.01) C07H 21/04 (2006.01) C12N 1/21 (2006.01) C12N 9/10 (2006.01) C12N 15/74 (2006.01)

Patent

CA 2584004

Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

La présente invention concerne des systèmes complets de PUFA PKS (pour "Poly Unsaturated Fatty Acid Poly Ketide Synthase" c'est-à-dire "synthase polykétidique d'acides gras polyinsaturés") provenant de micro-organismes bactériens, en l'occurrence Shewanella japonica et Shewanella olleyana, ainsi que des fragments biologiquement actifs et certains de leurs homologues. L'invention concerne plus particulièrement des acides nucléiques codant de tels systèmes PUFA PKS, des protéines et certains de leurs domaines comprenant de tels systèmes PUFA PKS, des OGM (végétaux ou biologiques) comprenant de tels systèmes PUFA PKS, et enfin des procédés de fabrication et d'utilisation de ces systèmes. L'invention concerne également des OGM (végétaux et micro-organismes) et des procédés permettant la production efficace de lipides enrichis en divers acides gras polyinsaturés (PUFA) ainsi que d'autres molécules bioactives par manipulation d'un système PUFA PKS.

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