Pulmonary delivery in treating disorders of the central...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 31/192 (2006.01) A61K 31/198 (2006.01) A61K 31/473 (2006.01) A61K 47/02 (2006.01) A61K 47/06 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61L 9/04 (2006.01) A61P 25/00 (2006.01) A61P 25/06 (2006.01) A61P 25/08 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2421974

A method for treating a disorder of the central nervous system includes administering to the respiratory tract of a patient a drug which is delivered to the pulmonary system, for instance to the alveoli or the deep lung. Particles that include the drug can be employed. Preferred particles have a tap density of less than about 0.4 g/cm3. In addition to the medicament, the particles can include other materials such as, for example, phospholipids, amino acids, combinations thereof and others. The drug is administered at a dose which is at least about two-fold less than the dose required by oral administration.

L'invention concerne un procédé de traitement d'un trouble du système nerveux central consistant à administrer par voie respiratoire un médicament délivré au système pulmonaire, par exemple aux alvéoles ou au fond des poumons. Des particules contenant ledit médicament peuvent également être employées. Les particules préférées présentent une densité après tassement inférieure à 0,4 g/cm?3¿. En plus du médicament, lesdites particules peuvent contenir d'autres éléments tels que des phospholipides, des acides aminés, des combinaisons de ceux-ci, et autres. Le médicament est administré dans une quantité au moins deux fois inférieure à la quantité requise par une administration orale.

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