Pulmonary delivery of a fluoroquinolone

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61K 31/496 (2006.01)

Patent

CA 2724009

A composition for pulmonary administration comprises a fluoroquinolone betaine, such as ciprofloxacin betaine, and an excipient. In one version, the particles have a mass median aerodynamic diameter from about 1 µm to about 5 µm, and the fluoroquinolone has a half life in the lungs of at least 1.5 hours. The composition is useful in treating an endobronchial infection, such as Pseudomonas aeruginosa, and is particularly useful in treating cystic fibrosis.

L'invention concerne une composition pour une administration pulmonaire qui comporte une fluoroquinolone bétaïne, telle que la ciprofloxacine bétaïne, et un excipient. Dans une version, les particules ont un diamètre aérodynamique moyen massique d'environ 1 µm à environ 5 µm, et la fluoroquinolone a une demi-vie dans les poumons d'au moins 1,5 heure. La composition, qui s'utilise dans le traitement d'une infection endobronchique, telle que par le Pseudomonas aeruginosa, est particulièrement utile dans le traitement de la mucoviscidose.

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