Pulmonary delivery of a nerve agent neutralizing enzyme

Details Pulmonary delivery of a nerve agent neutralizing enzyme Pulmonary delivery of a nerve agent neutralizing enzyme

A - Human Necessities

61

K

A61K 38/46 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61P 25/00 (2006.01) A61P 39/02 (2006.01)

Patent

CA 2577386

The present invention provides for non-invasive treatment of nerve agent poisoning by administering nerve agent neutralizing enzymes to the pulmonary epithelium of a subject, by inhalation, where they accumulate within the lungs. Localization of such enzymes in the pulmonary epithelium results in neutralization of the nerve agents at the lungs. As a result, nerve agents move by diffusion out of the blood through the pulmonary capillaries, duc to the organophosphorus nerve agents rapid diffusion across the cell membranes of the body via diffusion, down their concentration gradients. The present invention presents a practical method of administering nerve agent neutralizing enzymes, without requiring passage into the blood plasma, and without requiring blood plasma activity of the enzyme.

La présente invention concerne un traitement non invasif d'un empoisonnement par un agent neurotoxique par administration d'enzymes de neutralisation d'agent neurotoxique sur l'épithélium pulmonaire d'un sujet, par inhalation, où elles s'accumulent dans les poumons. La localisation de telles enzymes dans l'épithélium pulmonaire conduit à la neutralisation des agents neurotoxiques dans les poumons. En conséquence, les agents neurotoxiques se déplacent par diffusion depuis le sang à travers les capillaires pulmonaires, en raison de la diffusion rapide des agents neurotoxiques organophosphorés à travers les membranes cellulaires du corps, vers leurs gradients de concentration inférieurs. La présente invention propose un procédé pratique d'administration d'enzymes de neutralisation d'agent neurotoxique, sans nécessiter le passage dans le plasma sanguin, et sans nécessiter l'activité de l'enzyme dans le plasma sanguin.

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