Pulmonary delivery of active fragments of parathyroid hormone

A - Human Necessities – 61 – K

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A61K 38/29 (2006.01) A61K 9/14 (2006.01) A61K 9/72 (2006.01)

Patent

CA 2145418

Systemic delivery of parathyroid hormone to a mammalian host is accomplished by inhalation through the mouth of a dis- persion of an N-terminal fragment of PTH. It has been found that such respiratory delivery of the PTH fragment provides a pul- satile concentration profile of the PTH in the host's serum. PTH fragment compositions include dry powder formulations having the PTH present in a dry bulking powder, liquid solutions or suspensions suitable for nebulization, and aerosol propellants suit- able for use in a metered dose inhaler.

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