Pulmonary delivery of polyene antifungal agents

Details Pulmonary delivery of polyene antifungal agents Pulmonary delivery of polyene antifungal agents

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2432319

The present invention provides spray-dried polyene compositions for oral inhalation to the lung. The polyene antifungal compositions demonstrate superior aerosol properties, do not exhibit appreciable degradation of the polyene upon spray-drying, and are useful in the treatment and prophylaxis of both pulmonary and systemic fungal infections.

La présente invention concerne des compositions polyène séchées par atomisation destinées à une inhalation pulmonaire par voie orale. Ces compositions antifongiques polyène présentent des propriété d'aérosol supérieures, ne présentent pas de dégradation notable du polyène lors du séchage par atomisation, et conviennent pour le traitement et la prophylaxie des infections fongiques systémiques et pulmonaires.

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