Pulmonary surfactant formulations

Details Pulmonary surfactant formulations Pulmonary surfactant formulations

A - Human Necessities

61

K

A61K 31/661 (2006.01) A61K 9/00 (2006.01) A61K 31/20 (2006.01) A61K 31/215 (2006.01) A61K 31/56 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) C07K 14/785 (2006.01)

Patent

CA 2595162

Synthetic pulmonary surfactant compositions comprising dipalmitoyl phosphatidylcholine, phosphatidylglycerol, and essentially neutral lipid, and having essentially no 1-palmitoyl 2-oleoyl phosphatidylglycerol and essentially no palmitic acid are provided. Methods for treating respiratory disease are also provided comprising administering a therapeutically effective amount of a synthetic pulmonary surfactant comprising dipalmitoyl phosphatidylcholine, phosphatidylglycerol, and essentially neutral lipid, and having essentially no 1-palmitoyl 2-oleoyl phosphatidylglycerol and essentially no palmitic acid.

L'invention concerne des compositions de tensioactif pulmonaire synthétiques comprenant une dipalmitoyl phosphatidylcholine, un phosphatidylglycérol et sensiblement un lipide neutre, et ne comprenant sensiblement pas de 1-palmitoyl 2-oleoyl phosphatidylglycérol et d'acide palmitique. L'invention concerne également des méthodes permettant de traiter des maladies respiratoires qui consistent à administrer une quantité thérapeutiquement efficace de tensioactif pulmonaire synthétique comprenant une dipalmitoyl phosphatidylcholine, un phosphatidylglycérol et sensiblement un lipide neutre et ne comprenant sensiblement pas de 1-palmitoyl 2-oleoyl phosphatidylglycérol et d'acide palmitique.

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