Pulsatile delivery of leptin receptor ligands

Details Pulsatile delivery of leptin receptor ligands Pulsatile delivery of leptin receptor ligands

A - Human Necessities

61

K

A61K 38/24 (2006.01) A61K 38/22 (2006.01)

Patent

CA 2282325

This invention provides a method for optimizing the administration of leptin receptor ligands to a mammal in need of such treatment. More specifically, this invention provides an improved method of delivering leptin receptor ligands to a mammal in need of such treatment comprising pulsatile or peak delivery of leptin receptor ligands to treat obesity and related conditions, including hyperglucocorticoidinemia, fertility or delayed puberty, and/or growth hormone deficiencies.

La présente invention concerne un procédé d'administration de ligand du récepteur de la leptine à un mammifère justifiant d'un tel traitement. En l'occurrence, l'invention porte sur un procédé amélioré d'administration de ligands du récepteur de la leptine à un mammifère justifiant d'un tel traitement, lequel procédé consiste à administrer en mode pulsatile des ligands du récepteur de la leptine de façon à traiter l'obésité et des états associés y compris l'hyperglucocorticoïdémie, la fertilité ou le retard de puberté, et/ou les déficiences en hormone de croissance.

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