Pulsatile delivery systems of biologically active agents...

A - Human Necessities – 61 – N

Patent

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A61N 1/30 (2006.01) A61N 1/32 (2006.01)

Patent

CA 2194010

The invention relates to a method for pulsed transport of a substance through tissue, the method comprising the steps of: (a) applying at least one electrical pulse to the tissue causes electroporation of the tissue region, the electrical pulse being applied for an electroporation pulse duration, the electroporation pulse duration being shorter than the driving force duration; (b) applying a driving force to the region of tissue whereby the driving force causes the substance to be transported through the tissue for a driving force duration; and (c) repeating step (a) during the driving force duration.

Procédé d'entraînement pulsé d'une substance dans un tissu, consistant: (a) à soumettre le tissu à au moins une impulsion électrique afin de provoquer l'électroporation de la zone tissulaire, la durée de l'impulsion électrique étant égale à la durée d'impulsion d'électroporation, et la durée d'impulsion d'électroporation étant inférieure à la durée d'une force motrice; (b) à soumettre la zone tissulaire à une force motrice de sorte que celle-ci provoque l'entraînement pulsé de la substance dans le tissu, et ce pendant la durée de la force motrice; et (c) à répéter l'étape (a) pendant la durée de la force motrice.

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