Pulsatile dosing of gossypol for treatment of disease

Details Pulsatile dosing of gossypol for treatment of disease Pulsatile dosing of gossypol for treatment of disease

A - Human Necessities

61

K

A61K 31/11 (2006.01) A61K 31/337 (2006.01) A61P 17/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2689033

This invention relates to pulsatile dose administration of gossypol or pharmaceutical compositions thereof for treating diseases, disorders and conditions responsive to gossypol, inhibiting the activity of anti-apoptotic Bcl-2 family proteins, inducing apoptosis in cells and increasing the sensitivity of cells to inducers of apoptosis.

La présente invention concerne l'administration en mode pulsatoire de doses de gossypol ou de compositions pharmaceutiques en contenant en vue du traitement de maladies, affections et troubles répondant au gossypol, en vue de l'inhibition de l'activité des protéines de la famille Bcl-2 anti-apoptique, ainsi qu'en vue de l'induction de l'apoptose dans les cellules et du renforcement de la sensibilité de celles-ci à des inducteurs de l'apoptose.

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