Pulsatile gastric retentive dosage forms

Details Pulsatile gastric retentive dosage forms Pulsatile gastric retentive dosage forms

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2694602

Dosage forms for delayed and pulsed release of therapeutic agents into the stomach are described. The dosage forms are gastric retentive dosage forms that achieve release of the therapeutic agent into the stomach and upper gastrointestinal tract subsequent to administration of the dosage form. The dosage forms find particular use in administration of acid-labile active agents such as proton pump inhibitors, and in treating gastric acid secretion such as gastroesophageal reflux disease (GERD) and nocturnal acid breakthrough (NAB).

L'invention porte sur des formes médicamenteuses pour une libération retardée et pulsée d'agents thérapeutiques dans l'estomac. Les formes médicamenteuses sont des formes médicamenteuses de rétention gastrique qui permettent une libération de l'agent thérapeutique dans l'estomac et le tractus gastro-intestinal supérieur après l'administration de la forme médicamenteuse. Les formes médicamenteuses trouvent une utilisation particulière dans l'administration d'agents actifs labiles sous l'action d'un acide, tels que des inhibiteurs de pompes à protons, et dans le traitement de la sécrétion d'acide gastrique telle que le syndrome de Barrett (GERD) et la sécrétion d'acide nocturne (NAB).

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