A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/182
A61K 31/65 (2006.01) A61K 9/50 (2006.01)
Patent
CA 2025703
Pharmaceutical delivery systems containing 7-dimethyl-6-deoxy-6-demethyltetracycline or a non-toxic said addition salt thereof comprising mixtures or separate administration units of pH sensitive polymer coated spherical granules adapted to release the minocycline in a medium having a pH of in the range of from about 4.0 to about 7.5 and coated or uncoated quick release granules adapted to release minocycline in a medium having a pH of less than about 3.9 or minocycline powder, pH adapted multi-coated compositions and oral dosage unit forms liquids, capsules or tablets containing the above are provided. These systems and formulations provide at least minimum therapeutic blood levels of minocycline for at least about 24 hours when administered to a subject only once-a-day. Methods for the preparation of the systems and formulations are provided as well.
Ellway Keith Anthony
Ganesan Madurai Gurusamy
Johnson Jerry Bain
Mooney Kieran George
Sheth Nitin Vadilal
American Cyanamid Company
Smart & Biggar
Wyeth Holdings Corporation
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