Pulsatile release compositions and methods for enhanced...

Details Pulsatile release compositions and methods for enhanced... Pulsatile release compositions and methods for enhanced...

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/26 (2006.01) A61K 9/56 (2006.01) A61K 31/7088 (2006.01)

Patent

CA 2458442

Modified release pharmaceutical formulations and methods for enhanced mucosal drug absorption. The formulation comprises initial population(s) of particles comprising both drug and penetration enhancer which are released at a first location in the gastrointestinal tract, and a subsequent population or populations of particles comprising a penetration enhancer(s) having a delayed release due to a polymeric coating or matrix. This penetration enhancer is released at an additional location( s ) in the intestine downstream from the first location and enhances absorption of the drug when it reaches the additional location(s).

L'invention concerne des formulations pharmaceutiques à libération modifiée et des procédés pour améliorer l'absorption de médicaments par voie muqueuse. Ces formulations comprennent une ou plusieurs populations initiales de particules comprenant un médicament et un activateur de pénétration qui sont libérés à un premier point du tractus gastro-intestinal, ainsi qu'une ou plusieurs autres populations de particules comprenant un ou plusieurs activateurs de pénétration présentant une libération différée grâce à un revêtement ou une matrice polymère. Ces activateurs de pénétration sont libérés à un ou plusieurs autres points de l'intestin en aval du premier point et ils améliorent l'absorption du médicament lorsque celui-ci atteint ce ou ces autres points.

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