C - Chemistry – Metallurgy – 12 – M
Patent
C - Chemistry, Metallurgy
12
M
C12M 3/00 (2006.01)
Patent
CA 2548464
Disclosed is a novel net member for supporting one or more cell constructs in the culture chamber of a bioreactor, which comprises an array of impermeable pyramidal elements protruding from the face thereof, wherein each of the corners of the base of each of said impermeable pyramidal elements comprises a circular opening. This net member provides for uniform and unobstructed flow of culture medium through 3D cell constructs in culture. Also disclosed are a bioreactor and bioreactor system incorporating said net member. The bioreactor and bioreactor system may be used in the bioproduction of therapeutic proteins and stem cell expansion.
L'invention concerne un nouvel élément de support permettant de supporter une ou plusieurs constructions cellulaires dans la chambre de culture d'un bioréacteur, comprenant un réseau d'éléments pyramidaux imperméables dépassant de la face de l'élément de support, chacun des coins de la base de chacune de ces éléments pyramidaux imperméables comportant une ouverture circulaire. Cet élément de support laisse circuler un flux uniforme et libre de milieu de culture à travers les constructions cellulaires 3D de la culture. L'invention concerne également un bioréacteur et un système de bioréacteur comprenant cet élément de support. Ce bioréacteur et ce système de bioréacteur peuvent être utilisés dans la bioproduction de protéines thérapeutiques et l'expansion de cellules souches.
Cohen Smadar
Dvir Tal
Shachar Michal
Ben-Gurion University Of The Negev Research And Development Auth
Goudreau Gage Dubuc
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