Pulsed cavitational ultrasound therapy

Details Pulsed cavitational ultrasound therapy Pulsed cavitational ultrasound therapy

A - Human Necessities

61

B

A61B 8/00 (2006.01)

Patent

CA 2623486

Therapy methods using pulsed cavitational ultrasound therapy can include the subprocesses of initiation, maintenance, therapy, and feedback of the histotripsy process, which involves the creation and maintenance of ensembles of microbubbles and the use of feedback in order to optimize the process based on observed spatial- temporal bubble cloud dynamics. The methods provide for the subdivision or erosion of tissue, liquification of tissue, and the enhanced delivery of therapeutic agents. Various feedback mechanisms allow variation of ultrasound parameters and provide control over the pulsed cavitational process, permitting the process to be tuned for a number of applications. Such applications can include specific tissue erosion, bulk tissue homogenization, and delivery of therapeutic agents across barriers.

La présente invention concerne des procédés thérapeutiques utilisant une thérapie par ultrasons par cavitation en impulsions qui peut comprendre les sous-processus d~initiation, de maintenance, de thérapie et de feedback du processus d~histotripsie, qui implique la création et la maintenance d'ensemble de microbulles et l'utilisation de feedback pour optimiser le processus basé sur des dynamiques de nuages de bulles spatiaux temporels observés. Les procédés s'appliquent à la subdivision, à l'érosion et à la liquéfaction de tissus et à l'administration améliorée d'agents thérapeutiques. Divers mécanismes de feedback permettent la variation de paramètres ultrasoniques et le contrôle du processus par cavitation en impulsions, ce qui permet de régler le processus sur un certain nombre d~applications. Ces applications pourront comprendre une érosion spécifique de tissus, l~homogénéisation de masse tissulaire et la livraison d~agents thérapeutiques au-delà de barrières.

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