Pure and stable tiotropium bromide

Details Pure and stable tiotropium bromide Pure and stable tiotropium bromide

C - Chemistry, Metallurgy

07

D

C07D 451/10 (2006.01) A61K 31/46 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2620142

This invention relates to solvates of tiotropium bromide having a purity of at least 99%, process for preparing such pure solvates, and their use in pharmaceutical, formulations. This invention also provides tiotropium bromide solvates containing less than about 0.15% area by HPLC of 2,2-dithienyl glycolic acid.

La présente invention concerne des solvates de bromure de tiotropium d~une pureté d~au moins 99%, un procédé pour la préparation de tels solvates purs et leur utilisation dans des formulations pharmaceutiques. La présente invention concerne également des solvates de bromure de tiotropium contenant moins d~environ 0,15 % en surface d~HPLC de l~acide 2,2-dithiénylglycolique.

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