C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/60 (2006.01) A61K 9/12 (2006.01) A61K 38/12 (2006.01) C07K 7/62 (2006.01)
Patent
CA 2242335
An anti-Pseudomonas aeruginosa agent which is substantially pure biologically active colistin component, a mixture thereof or a pharmaceutically acceptable salt thereof delivered as an aerosol or dry powder formulation. The figure shows a general structure of a prodrug colimycin (Figure 1A) and a generic formula of a drug colistin and its components substituents (Figure 1B). A formulation and method for preparation of substantially pure biologically active colistin component, a mixture thereof or a pharmaceutically acceptable salt thereof. A method for treatment and prophylaxis of Pseudomonas aeruginosa, Stenotrophomonas maltophilia or other susceptible pulmonary bacterial infections.
L'invention concerne un agent anti-Pseudomonas aeruginosa, qui est un composant de colistine sensiblement pur et biologiquement actif, un mélange dudit composant ou de l'un de ses sels pharmaceutiquement acceptables, ledit composant étant administré sous forme de formulation aérosol ou de poudre sèche. L'invention se rapporte également à une formulation et une méthode utilisées pour la préparation de colistine sensiblement pure et biologiquement active, à ses composants, à ses mélanges et à ses sels pharmaceutiquement acceptables. L'invention concerne en outre une méthode de traitement préventif et curatif de Pseudomonas aeruginosa, de Stenotrophomonas maltophilia ou d'autres infections bactériennes pulmonaires sensibles.
Montgomery Alan B.
Vandevanter Donald R.
Gowling Lafleur Henderson Llp
Pathogenesis Corporation
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