Pure enantiomers of 4,5-disubstituted .alpha.-butyrolactams,...

Details Pure enantiomers of 4,5-disubstituted .alpha.-butyrolactams,... Pure enantiomers of 4,5-disubstituted .alpha.-butyrolactams,...

C - Chemistry, Metallurgy

07

D

167/233, 260/251

C07D 207/28 (2006.01) A61K 31/4015 (2006.01) C07D 207/26 (2006.01) C07D 207/273 (2006.01) C07D 241/08 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01)

Patent

CA 1341159

The invention provides pure enatiomers of 4,5-disubstituted .gamma.-butyrolactams of the general formula (see formula I) By means of the pure enantiomers of 4,5-disubstituted .gamma.-butyrolactams (I), according to the invention, it is now possible to synthesize (+)-(3R),(4S),(5S),(7R)-3-hydroxy- 5-.alpha.-hydroxybenzyl-1-methyl-4-phenyl-pyrrolidin-2-one and derivatives in the form of pure enantiomers.

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