Purging of cells using viruses

Details Purging of cells using viruses Purging of cells using viruses

C - Chemistry, Metallurgy

12

N

C12N 5/078 (2010.01) A61K 35/12 (2006.01) A61K 35/28 (2006.01) A61K 35/76 (2006.01)

Patent

CA 2412493

The subject invention relates to viruses that are able to purge (reduce or eliminate) undesirable cells in a mixture of cells. Undesirable cells can include neoplastic cells, cells mediating graft-versus hot diseases, and autoimmune cells. The subject invention also relates to the purging of undesirable cells from bone marrow or peripheral blood cells harvests in the treatment of mammals including cancer patients, transplant recipients and patients with autoimmune disease.

L'invention se rapporte à des virus qui peuvent purger (diminuer ou éliminer) des cellules indésirables dans un mélange de cellules. Des cellules indésirables peuvent inclure des cellules néoplastiques, des cellules induisant une réaction du greffon contre l'hôte, ou des cellules autoimmunes. L'invention se rapporte également à l'élimination de cellules indésirables de la moelle osseuse ou de prélèvements du sang périphérique lors du traitement d'un mammifère, notamment de patients atteints de cancer, de receveurs d'organe, ou de patients atteints d'une maladie autoimmune.

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