Purification and crystalline forms of zapelon

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 25/20 (2006.01) G01N 30/02 (2006.01)

Patent

CA 2453751

A purification process that is capable of separating zaleplon and a regioisomer of zaleplon that tends to form as a byproduct in the chemical synthesis of zaleplon, resulting in essentially pure zaleplon, is disclosed. In addition, novel crystal forms of zaleplon are accessible with the process.

Cette invention concerne un procédé de purification permettant de séparer le zaleplon et un regioisomère de zaleplon qui tend à former sous forme de produit secondaire dans la synthèse chimique du zaleplon, procédé qui permet d'obtenir du zaleplon essentiellement pur. De plus, ce procédé donne accès à de nouvelles formes cristallines de zaleplon.

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