Purification and use of a factor for supporting wound healing

Details Purification and use of a factor for supporting wound healing Purification and use of a factor for supporting wound healing

C - Chemistry, Metallurgy

07

K

C07K 1/14 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/36 (2006.01) C07K 1/18 (2006.01) C07K 1/22 (2006.01) C07K 1/34 (2006.01) C07K 1/36 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2640010

A process for manufacturing of a composition containing a purified factor for supporting wound healing selected from the group consisting of Hepatocyte Growth Factor (HGF) platelet derived growth factor (PDGF), Epidermal growth factor (EGF), transforming growth factor alfa (TGF-.alpha.), Transforming growth factor beta (TGF-.beta.), insulin like growth factor (IGF-I) and Fibroblast growth factor (FGF) from sources, such as blood, containing the factor for supporting wound healing, wherein the manufacturing process comprises purification steps which are performed in the presence of antithrombin III (AT-III).

L~invention concerne un procédé de fabrication d~une composition contenant un facteur purifié destiné à favoriser la cicatrisation des blessures. Ledit facteur est choisi dans le groupe comprenant le facteur de croissance des hépatocytes (HGF), le facteur de croissance dérivé des plaquettes (PDGF), le facteur de croissance épidermique (EGF), le facteur de croissance transformant alpha (TGF-.alpha.), le facteur de croissance transformant bêta (TGF-.beta.), le facteur de croissance analogue à l~insuline (IGF-I) et le facteur de croissance des fibroblastes (FGF), lesdits facteurs provenant de sources telles que le sang les contenant. Ledit procédé de fabrication comprend des étapes de purification réalisées en présence d~antithrombine III (AT-III).

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