Purification, detection and methods of use of protease nexin-2

Details Purification, detection and methods of use of protease nexin-2 Purification, detection and methods of use of protease nexin-2

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 38/55 (2006.01) C07K 16/38 (2006.01) C12N 5/18 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2079880

2079880 9116628 PCTABS00008 Immunopurification of Protease Nexin-2 and .beta. amyloid precursor protein is disclosed. Methods of detecting Protease Nexin-2 and the use of these methods in the diagnosis of Alzheimer's disease and other conditions are also disclosed. Additionally, pharmaceutical preparations including Protease Nexin-2 or modified forms thereof are disclosed. Medical uses for the pharmaceutical preparations are also disclosed. These uses include the treatment and prevention of amyloid plaques in Alzheimer's disease and Down's Syndrome.

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