C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/785 (2006.01) C07K 1/20 (2006.01)
Patent
CA 2136734
ABSTRACT FOR THE DISCLOSURE The present invention is directed to a purification method for hydrophobic polypeptides by using high performance liquid chromatography, characterized by using a mixed solvent as a moving phase, in which the portion of trifluoroacetic acid is from 3 to 10% by volume, and polyvinyl alcohol-based column filler in the said high performance liquid chromatography. The method according to the present invention is useful as a purification method for hydrophobic polypeptides in view of the fact that the pulmonary surfactant, which is prepared from the hydrophobic polypeptide purified according to the method of the present invention. shows better surface active property than the hydrophobic polypeptides purified by customary methods for the purification.
Aiba Toshimitsu
Fujiwara Tetsuro
Sakai Kaoru
Takei Tsunetomo
Gowling Lafleur Henderson Llp
Mitsubishi-Tokyo Pharmaceuticals Inc.
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