Purification method for proteins

C - Chemistry – Metallurgy – 07 – K

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167/129, 530/7.1

C07K 1/36 (2006.01) C07K 14/525 (2006.01)

Patent

CA 1286843

Abstract of the Disclosure Tumor necrosis factor (TNF) may be purified using a hydrophobic support in a chromatographic column that is then developed, preferably using high pressure liquid chromatography. Also, recombinantly produced biologically active proteins may be purified by passing a solution containing the protein through a continuous porous hydrophobic membrane, and recovering the fraction enriched in the desired protein. TNF and recombinant ricin toxin A chain may be purified. A highly purified TNF comprising at least 95%, TNF, as determined by SDS-PAGE analysis, with an endotoxin content of less than 0.1 nm/mg TNF that is substantially free of pyrogens by the USP rabbit pyrogen test at a dosage range of 1.0 to 2.4 x 105 U/Kg is obtained.

518943

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