Purification method of...

C - Chemistry – Metallurgy – 07 – C

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C07C 229/36 (2006.01) C07C 227/42 (2006.01)

Patent

CA 2407681

The present invention is to provide a purification method of obtaining N-(1(S)- ethoxycarbonyl-3-phenylpropyl)-L-alanine of high quality in good yield with high productivity, which is accordingly suited for commercial scale application. An impurity-contaminated N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L- alanine is crystallized from a mixed solvent of alcohol and water in a volume ratio of alcohol/water being 1 to 20 to remove a contaminating impurity into a mother liquor and give crystals of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L- alanine.

La présente invention se rapporte à un procédé de purification permettant d'obtenir de la N-(1(S)-éthoxycarbonyl-3-phénylpropyl)-L-alanine de qualité supérieure et avec un rendement élevé, ledit procédé étant par conséquent adapté à une application d'échelle commerciale. De la N-(1(S)-éthoxycarbonyl-3-phénylpropyl)-L-alanine contaminée par des impuretés est cristallisée à partir d'un solvant contenant un mélange d'alcool et d'eau et ayant un rapport volumique alcool/eau compris entre 1 et 20 de manière à extraire une impureté contaminante dans une liqueur mère et à produire des cristaux de N-(1(S)-éthoxycarbonyl-3-phénylpropyl)-L-alanine.

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