Purification of alpha-1 proteinase inhibitor using novel...

Details Purification of alpha-1 proteinase inhibitor using novel... Purification of alpha-1 proteinase inhibitor using novel...

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) C07K 1/18 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2692337

Cation chromatography with solutions at pH less than 6.0 and low ionic strength can be utilized to purify human .alpha.-1 proteinase inhibitor (.alpha.-1 PI) from biological fluids including plasma and plasma fractions. The cation chromatography takes advantage of the fact that active .alpha.-1 PI does not bind to the cation column under these conditions but other proteins, including denatured .alpha.-1 PI and albumin, do. The effect is that active .alpha.-1 PI flows through the chromatography column leaving the contaminating proteins behind. Recovery of .alpha.-1 PI is high and improvement of purity is dramatic.

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